Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain unknown. In this double-blind, randomized ...

The Race and Medicine collection reflects NEJM’s commitment to understanding and combating racism as a public health and human rights crisis. Our commitment to antiracism includes efforts to ...

Dr. Brian Y. Chang (Medicine): A 62-year-old man was admitted to this hospital because of abdominal pain. Two years before the current presentation, postprandial abdominal pain developed.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

This is a retrospective study of the history, roentgenology and autopsy pathology when appropriate of all infants with severe respiratory-distress syndrome who required twenty-four hours or more ...

Chemoimmunotherapy was the standard treatment for chronic lymphocytic leukemia (CLL), although it has now been largely replaced by targeted therapies. 1-3 Available targeted therapies include ...

How are patients with myocardial scar after a myocardial infarction and ventricular tachycardia currently managed? Implantable cardioverter–defibrillators (ICDs) improve survival in patients ...

Welcome and thank you for considering the New England Journal of Medicine (NEJM) as a venue for your work. As the oldest continuously-published medical journal, our mission since 1812 has been to ...

We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel ...

Dr. Carlos A. Portales Castillo (Medicine): A 30-year-old woman was admitted to this hospital because of headache and dysesthesia. The patient had been in her usual state of good health until 8 ...

Two years of empagliflozin treatment in patients with chronic kidney disease slowed progression and reduced cardiovascular risk. Findings from a 2-year post-trial follow-up are summarized in a ...

The WHO advises using fractional doses of the 17D yellow fever vaccine when outbreaks occur during vaccine shortages, but evidence on the immunogenicity of these lower doses is limited. New ...