Major Finding: Cancer cells transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes (TIL) that impair antitumor activity. Concept: Deubiquitinase USP30 protects cancer cell-derived ...

1Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota. *Corresponding Author: Jann N. Sarkaria, Department of Radiation Oncology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905.

1Department of Radiation Oncology, Inselspital Bern University Hospital, Bern, Switzerland. 2Department for BioMedical Research, Radiation Oncology, University of Bern, Bern, Switzerland. 3Graduate ...

Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes. Concept: Ongoing ...

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The FDA’s Center for Drug Evaluation and Research issued its annual report on the approval of drugs, which announced that the agency OK’d 50 novel drugs in 2024, 15 of which were related to cancer ...

The U.S. National Science Foundation (NSF) announced that payments have been restored to the researchers who receive funding from the independent federal agency. Grant-recipients’ salaries were ...

Trophoblast cell surface antigen 2 (TROP2) is a promising target for cancer therapy. Here, Li and colleagues present the preclinical evaluation of OBI-992, a TROP2-targeted antibody-drug conjugate ...

1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.

1Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate ...

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...

At today’s Senate Health, Education, Labor, and Pensions Committee hearing, nominee for Secretary of the Department of Health and Human Services Robert F. Kennedy (RFK) Jr. refused to renounce his ...