We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel ...

The Race and Medicine collection reflects NEJM’s commitment to understanding and combating racism as a public health and human rights crisis. Our commitment to antiracism includes efforts to ...

Food and nutrition security exists when all people at all times have access to nutritious food for the prevention and treatment of disease and the promotion of health and well-being. Food and ...

Dr. Carlos A. Portales Castillo (Medicine): A 30-year-old woman was admitted to this hospital because of headache and dysesthesia. The patient had been in her usual state of good health until 8 ...

Seventeen patients with Parkinsonism were admitted to this study. All had been referred to us by their physicians, after treatment with several standard medications for relief of this disorder ...

Three of the authors served as editors-in-chief of MMWR: Dr. Rasmussen from 2015 to 2018, Dr. Lindegren from 2005 to 2006, and Dr. Altman from 1963 to 1964.Dr. Iademarco served as director of the ...

Familial HLH is a success story in modern medicine. Initially a disease that was largely unknown and fatal, it is now understood on a molecular level and is curable. Moreover, HLH is an archetype ...

How are patients with myocardial scar after a myocardial infarction and ventricular tachycardia currently managed? Implantable cardioverter–defibrillators (ICDs) improve survival in patients ...

The deluge of legislative and policy attacks on diversity, equity, and inclusion efforts threatens the integrity of the health care workforce and will ultimately worsen the health of the populace.

Welcome and thank you for considering the New England Journal of Medicine (NEJM) as a venue for your work. As the oldest continuously-published medical journal, our mission since 1812 has been to ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...